🧪 Chemistry Mysteries

Can we predict how a protein will fold based solely on its amino acid sequence? Despite AlphaFold's breakthrough achieving ~90% accuracy, the complete understanding of protein folding mechanisms remains elusive.

How did simple organic molecules become self-replicating systems that eventually led to life? The chemical pathways from non-living matter to the first living cells remain one of science's greatest mysteries.

Why do biological molecules exhibit a preference for one chirality over another? All amino acids in proteins are left-handed, and all sugars in DNA are right-handed, but the origin of this asymmetry is unknown.

Can we create materials that conduct electricity with zero resistance at room temperature? Such materials would revolutionize technology, from power transmission to quantum computing.

Can we create artificial systems that efficiently convert sunlight, water, and CO₂ into useful fuels like hydrogen or hydrocarbons? Mimicking nature's most important chemical process could solve energy and climate challenges.

How can we design catalysts that are 100% selective, highly active, and completely stable? Understanding catalysis at the molecular level could revolutionize chemical manufacturing and reduce environmental impact.

Can we create practical lithium-air batteries with energy densities approaching gasoline? These batteries could revolutionize electric vehicles and grid storage, but fundamental chemistry challenges remain unsolved.